Search on: ANGIOTENSIN-CONVERTING ENZYME INHIBITORS 
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Descriptor English:   Angiotensin-Converting Enzyme Inhibitors 
Descriptor Spanish:   Inhibidores de la Enzima Convertidora de Angiotensina 
Descriptor Portuguese:   Inibidores da Enzima Conversora de Angiotensina 
Synonyms English:   Kininase II Inhibitors
ACE Inhibitors  
Tree Number:   D27.505.519.389.745.085
Definition English:   A class of drugs whose main indications are the treatment of hypertension and heart failure. They exert their hemodynamic effect mainly by inhibiting the renin-angiotensin system. They also modulate sympathetic nervous system activity and increase prostaglandin synthesis. They cause mainly vasodilation and mild natriuresis without affecting heart rate and contractility. 
Indexing Annotation English:   protease inhib & antihypertensives; DF: ACE INHIB
History Note English:   88; ANGIOTENSIN I-CONVERTING ENZYME INHIBITOR was see TEPROTIDE 1991-93 
Allowable Qualifiers English:  
AD administration & dosage AE adverse effects
AG agonists AN analysis
BL blood CF cerebrospinal fluid
CS chemical synthesis CH chemistry
CL classification CT contraindications
DU diagnostic use EC economics
HI history IM immunology
IP isolation & purification ME metabolism
PK pharmacokinetics PD pharmacology
PO poisoning RE radiation effects
ST standards SD supply & distribution
TU therapeutic use TO toxicity
UR urine  
Record Number:   22832 
Unique Identifier:   D000806 

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